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INHALE Publications

Journal articles

Enne, V.I., Stirling, S., Barber, J.A.et al. INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia. Intensive Care Med (2025).

Stewart SF, Pandolfo AM, Jani Y et al. 2025Guidelines vs mindlines: a qualitative investigation of how clinicians’ beliefs influence the application of rapid molecular diagnostics in intensive care. Antimicrob Agents Chemother 0:e01156-24.

SJ Stewart, A Pandolfo, Z Moon et al. (2024). UK clinicians’ attitudes towards the application of molecular diagnostics to guide antibiotic use in ICU patients with pneumonias: a quantitative study. Journal of Antimicrobial Chemotherapy. 79 (1):123-127.

V I Enne, A Aydin, R Baldan et al. (2022). Multicentre evaluation of two multiplex PCR platforms for the rapid microbiological investigation of nosocomial pneumonia in UK ICUs: the INHALE WP1 study.Thorax. 77(12):1220-1228.

A. Pandolfo, R. Horne, Y. Jani et al. (2022). Understanding decisions about antibiotic prescribing in ICU:an application of the Necessity Concerns Framework. BMJ Quality and Safety 31:199-210

J High, V I Enne, JA Barber et al. (2021). INHALE: the impact of using FilmArray Pneumonia Panel molecular diagnostics for hospital-acquired and ventilator-associated pneumonia on antimicrobial stewardship and patient outcomes in UK Critical Care-study protocol for a multicentre randomised controlled trial. Trials 22:680

A. Pandolfo, R. Horne, Y. Jani et al. (2021). Intensivists' beliefs about rapid multiplex molecular diagnostic testing and its potential role in improving prescribing decisions and antimicrobial stewardship: a qualitative study. Antimicrobial Resistance and Infection Control 10:95

A. P. Wagner, V. I Enne, D. M Livermore et al. (2020). A review of health economic models and Ventilator Associated pneumonia (VAP).Journal of Hospital Infection. 106:745-56

Z. Dhesi, V. I. Enne, J. O’Grady et al. (2020) Rapid and Point-of-Care Testing in Respiratory Tract Infections: An Antibiotic Guardian? ACS Pharmacology and Translational Science. 3: 401–417.

Charalampous T, Kay GL, Richardson H, et al. Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection. Nat Biotechnol. 2019;37(7):783-92.

Pre-print

Z. Dhesi, V. I. Enne, D.Brealey et al. 2020. Organisms causing secondary pneumonias in COVID-19 patients at 5 UK ICUs as detected with the FilmArray test. MedRvix

WP3 Statistical Analysis Plan

https://norwichcrtu.uea.ac.uk/ctudocs_public/inhale/Analysis%20plan%20v1.0%20-%20INHALE%2022-02-2022.pdf

Health Economic Analysis Planhttps://norwichcrtu.uea.ac.uk/ctudocs_public/inhale/heap_1_4.pdf

Thesis

Z. Dhesi. 2021. Rapid Diagnosis and Treatment of Hospital-acquired and Ventilator-associated Pneumonia in Intensive Care Unit Patients. Doctoral thesis (M.D (Res)), UCL (University College London)